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Previous and Current Projects – REC

HomeCenter on Aging and Health  > OAIC  > OAIC Cores  > Research Education Component  > Previous and Current Projects – REC

Previous and Current Projects – REC

Research Education Component

Overview

OAIC-Supported Junior Faculty:

07/01/2022-06/30/2023 (Year 20) 

  • Hladek, Melissa: “Using Human-Centered Design to Adapt CAPABLE as a Prehabilitation Intervention for Adults with Frailty Awaiting Kidney Transplant.”
  • Keceli, Gizem: “Dissecting the Mechanisms Whereby Tryptophan Metabolites Alter Myocardial Function.”
  • Laskow, Thomas: ““Physical Frailty, Inflammation, and Response to Clinical Stressors.”
  • Nidadavolu, Lolita: “Identifying mechanisms by which circulating-cell free DNA contribute to increased TNFR1 in frailty.”
  • Pena Dias, Jenny: “Alterations in the gonadal axis and frailty in aging men with HIV.” [Note: support ended early due to K award]
  • Rowan, Nicholas: “The implications of olfaction with frailty, a population-based and exploratory investigation.”
  • Wang, Qinchuan: “CaMKII oxidation links oxidative stress to inflammation, frailty, and premature death.”

07/01/2021-06/30/2022 (Year 19) 

  • Hladek, Melissa: “Using Human-Centered Design to Adapt CAPABLE as a Prehabilitation Intervention for Adults with Frailty Awaiting Kidney Transplant.”
  • Keceli, Gizem: “Dissecting the Mechanisms Whereby Tryptophan Metabolites Alter Myocardial Function.”
  • Nidadavolu, Lolita: “Identifying mechanisms by which circulating-cell free DNA contribute to increased TNFR1 in frailty.”
  • Phillip, Jude: “Development and validation of dynamic cell-based biomarkers of healthy ageing.”
  • Rowan, Nicholas: “The implications of olfaction with frailty, a population-based and exploratory investigation.”

07/01/2020-06/30/2021 (Year 18) 

  • Ambale-Venkatesh, Bharath: “Pathways leading to frailty: a study of muscle, cardiovascular tissue, and energy utilizing whole-body magnetic resonance imaging.”
  • Lewsey, Sabra: “Understanding frailty risk factors in older individuals with heart failure with preserved ejection fraction.” (received Diversity Supplement award)
  • Phillip, Jude: “Development and validation of dynamic cell-based biomarkers of healthy ageing.”
  • Westbrook, Reyhan: “Metabolomic differences in energy utilization and Kyn/Trp metabolism pathways in mouse models of frailty: evidence-based implication for translational studies in humans.” (received K award)

07/01/2019-06/30/2020 (Year 17) 

  • Ambale-Venkatesh, Bharath: “Pathways leading to frailty: a study of muscle, cardiovascular tissue, and energy utilizing whole-body magnetic resonance imaging.”
  • Sheehan, Orla: “Frailty and compensatory mechanisms for managing treatment burden, treatment adherence, and adverse outcomes in homebound older adults.”
  • Westbrook, Reyhan: “Metabolomic differences in energy utilization and Kyn/Trp metabolism pathways in mouse models of frailty: evidence-based implication for translational studies in humans.”
  • Wu, Pei-Hsun: “Biophysical cellular characteristics in frail and non-frail older adults.”

07/01/2018-06/30/2019 (Year 16) 

  • Ambale-Venkatesh, Bharath: “Pathways leading to frailty: a study of muscle, cardiovascular tissue, and energy utilizing whole-body magnetic resonance imaging.”
  • Damluji, Abdulla: “Consequences of Frailty in Older Adults after Acute Coronary Syndrome” (received K award)
  • Sheehan, Orla: “Frailty and compensatory mechanisms for managing treatment burden, treatment adherence, and adverse outcomes in homebound older adults.”
  • Westbrook, Reyhan: “Metabolomic differences in energy utilization and Kyn/Trp metabolism pathways in mouse models of frailty: evidence-based implication for translational studies in humans.”
  • Wu, Pei-Hsun: “Biophysical cellular characteristics in frail and non-frail older adults.”

07/01/2017-06/30/2018 (Year 15) 

  • Chung, Tae Hwan: “Involvement of Kynurenine and NAD Pathways in Frailty.” (received K award)
  • Damluji, Abdulla: “Consequences of Frailty in Older Adults after Acute Coronary Syndrome”

07/01/2016-06/30/2017 (Year 14) 

  • Chung Tae Hwan: “Involvement of Kynurenine and NAD Pathways in Frailty.”
  • Hasan, Rani: “Frailty in Elderly Patients Undergoing Transcatheter Aortic Valve Replacement (TAVR) for Symptomatic Severe Aortic Valve Stenosis: Impact on Outcomes, Effect of TAVR on the Frailty Phenotype, and Association with Inflammation.”

07/01/2015-06/30/2016 (Year 13) 

  • Brown, Charles: “The association between baseline frailty and postoperative delirium or functional decline after cardiac surgery, and a potential intervention to improve outcomes.” (received K award)
  • Gross, Alden: “Intersection of Domain-specific Cognitive Performance and Frailty: An Integrative Data Analysis.” (received K award)
  • Hasan, Rani: “Frailty in Elderly Patients Undergoing Transcatheter Aortic Valve Replacement (TAVR) for Symptomatic Severe Aortic Valve Stenosis: Impact on Outcomes, Effect of TAVR on the Frailty Phenotype, and Association with Inflammation.”

07/01/2014-06/30/2015 (Year 12)

  • Brown, Charles: “The association between baseline frailty and postoperative delirium or functional decline after cardiac surgery, and a potential intervention to improve outcomes.”
  • Gross, Alden: “Intersection of Domain-specific Cognitive Performance and Frailty: An Integrative Data Analysis.”
  • Hasan, Rani: “Frailty in Elderly Patients Undergoing Transcatheter Aortic Valve Replacement (TAVR) for Symptomatic Severe Aortic Valve Stenosis: Impact on Outcomes, Effect of TAVR on the Frailty Phenotype, and Association with Inflammation.”

07/01/2013-06/30/2014 (Year 11)

  • Agrawal, Yuri: “Vestibular impairments and postural instability, gait impairments, frailty and falls in older adults” (received K award)
  • McAdams-Demarco, Mara: “Clinical management older ESRD patients undergoing kidney transplantation (KT) through the development of adverse outcome metrics and risk prediction relevant to older adults.” (received K award)

07/01/2012-06/30/2013 (Year 10)

  • Dobrosielski, Devon: “Effects of a Lifestyle Intervention in Older Adults with Sleep Apnea”
  • Kalyani, Rita: “Hyperglycemia, Muscle Loss, and Frailty” (received K award)
  • Pustavoitau, Aliaksei: “A Prospective Cohort Study Evaluating the Use of p16INK4a Transcriptional Factor Level as a Marker of Molecular Age and Predictor of Perioperative Outcomes”

07/01/2011-06/30/2012 (Year 9)

  • Dobrosielski, Devon: “Effects of a Lifestyle Intervention in Older Adults with Sleep Apnea”
  • Kalyani, Rita: “Hyperglycemia, Muscle Loss, and Frailty”
  • Pustavoitau, Aliaksei: “A Prospective Cohort Study Evaluating the Use of p16INK4a Transcriptional Factor Level as a Marker of Molecular Age and Predictor of Perioperative Outcomes”

07/01/2010-06/30/2011 (Year 8)

  • Abadir, Peter : “Age Related Change in Angiotensin Receptors and Its Contribution to Chronic Inflammation” (received K23 award)
  • Dobrosielski, Devon: “Effects of a Lifestyle Intervention in Older Adults with Sleep Apnea”
  • Lin, Frank: “Hearing Loss and Frailty” (received K23 award)
  • Pustavoitau, Aliaksei: “A Prospective Cohort Study Evaluating the Use of p16INK4a Transcriptional Factor Level as a Marker of Molecular Age and Predictor of Perioperative Outcomes”
  • Roy, Cindy : “Mechanisms of anemia associated with chronic inflammation and aging in mice”
  • Wang, George: “Long-term maintenance of viral T-cell immunity and T-cell repertoire diversity in the aging immune system”  (received K23 award)

07/01/2009-06/30/2010 (Year 7)

  • Roy, Cindy : “Mechanisms of anemia associated with chronic inflammation and aging in mice”
  • Tan, Erwin: “Effect of the Baltimore Experience Corps Study on Walking Activity and the Characteristics of Walking”
  • Wang, George: “Potential targets along the pathophysiologic pathway of frailty amenable to preventive and therapeutic interventions”

07/01/2008-06/30/2009 (Year 6)

  • Roy, Cindy : “Mechanisms of anemia associated with chronic inflammation and aging in mice”
  • Tan, Erwin: “Effect of the Baltimore Experience Corps Study on Walking Activity and the Characteristics of Walking”
  • Wang, George: “Potential targets along the pathophysiologic pathway of frailty amenable to preventive and therapeutic interventions”

06/01/2007-05/31/2008 (Year 5)

  • Makary, Martin: “Frailty Syndrome in Surgical Patients”
  • Polotsky, Vsevolod: “Effect of Chronic Intermittent Hypoxia on Frailty”
  • Seplaki, Chris: “Expanding the scope of frailty research: modeling multiple physiological systems, delineation among alternative frameworks, and the social context of frailty” (received K award)
  • Varadhan, Ravi: “Identifying frailty using non-invasively measured dynamic physiological signals”
  • Weiss, Carlos: “The Relationship between Frailty and Basal Metabolic Rate”

06/01/2006-05/31/2007 (Year 4)

  • Crentsil, Victor: “L-carnitine deficiency and the development of frailty and disability in   older adults”
  • Makary, Martin: “Frailty Syndrome in Surgical Patients”
  • Seplaki, Chris: “Expanding the scope of frailty research: modeling multiple physiological systems, delineation among alternative frameworks, and the social context of frailty”
  • Weiss, Carlos: “The Relationship between Frailty and Basal Metabolic Rate”

06/01/2005-05/31/2006 (Year 3)

  • Boyd, Cynthia: “Characterization of functional decline and recovery after hospitalization”
  • Carlson, Michelle: “Characterize cognitive reserve by examining with-cognitive-tests performance decays over time”
  • Leng, Sean: “Contributions of serum IL-6 level and total/differential WBC to frailty and mortality”
  • Yuh, David: “Impact of Frailty on Outcomes in Older Patients Undergoing Cardiac Surgery”

06/01/2004-05/31/2005 (Year 2)

  • Boyd, Cynthia: “Characterization of functional decline and recovery after hospitalization”
  • Carlson, Michelle: “Characterize cognitive reserve by examining with-cognitive-tests performance decays over time”
  • Chaves, Paulo: “Heart Rate (HR) Variability and Complexity and Frailty Status in Older Women”
  • Leng, Sean: “Contributions of serum IL-6 level and total/differential WBC to frailty and mortality”
  • Yuh, David: “Impact of Frailty on Outcomes in Older Patients Undergoing Cardiac Surgery”

06/01/2003-05/31/2004 (Year 1)

  • Boyd, Cynthia: “Characterization of functional decline and recovery after hospitalization”
  • Carlson, Michelle: “Characterize cognitive reserve by examining with-cognitive-tests performance decays over time”
  • Chaves, Paulo: “Heart Rate (HR) Variability and Complexity and Frailty Status in Older Women”
  • Leng, Sean: “Contributions of serum IL-6 level and total/differential WBC to frailty and mortality”
  • Yuh, David: “Impact of Frailty on Outcomes in Older Patients Undergoing Cardiac Surgery”