Pilot/Exploratory Studies Core
Overview
Key Accomplishments
Available Resources
Key Personnel
OAIC-Supported Pilot Studies
07/01/2022-06/30/2023 (Year 20):
- Najim Dehak, PhD, and Laureano Moro Velazquez, PhD: “Artificial intelligence-based phenotypic biosignals of frailty.”
- Nicola Heller, PhD, and Franco D’Alessio, MD: ““Investigating changes in monocyte-macrophage phenotype and inflammation in older frail adults.”
- Lee Goeddel, MD, MPH: “A Pilot Study to Identify Frail Patients Prior to Surgery and Implement a Novel Social Work- Focused Preoperative Intervention.”
- Sashank Reddy, MD, PhD: “Uncovering the role of chronic inflammatory signals in frailty and regenerative decline in aged skin.”
- Amal Wanigatunga, PhD: “The Effects of a Proof-of-Concept Sedentary Reduction Program on Metabolism in Prefrail Older Adults.”
07/01/2021-06/30/2022 (Year 19):
- Lee Goeddel, MD, MPH: “A Pilot Study to Identify Frail Patients Prior to Surgery and Implement a Novel Social Work- Focused Preoperative Intervention.”
- Thorsten Leucker, MD, PhD: “PCSK9 Links Age and Frailty related Inflammation to Endothelial Cell Dysfunction”
- Reyhan Westbrook, PhD: “The Effects of Tryptophan Degradation Pathway Manipulation on Metabolism, Healthspan and Lifespan in Mice.”
07/01/2020-06/30/2021 (Year 18):
- Janiece Taylor, PhD: “Pilot Behavioral Intervention to Address Pain and Frailty in Older African-American Women.”
- Anne Le, MD: “Metabolomics Energy Signatures of Frailty.”
- Thorsten Leucker, MD, PhD: “PCSK9 Links Age and Frailty related Inflammation to Endothelial Cell Dysfunction”
- Tae Chung, MD: ” Effects of Neurotoxic Kynurenines on Peripheral Nerve Regeneration.”
- Reyhan Westbrook, PhD: “The Effects of Tryptophan Degradation Pathway Manipulation on Metabolism, Healthspan and Lifespan in Mice.”
- Kathy Wilson, PhD: “Analysis of lamin A/C-associated proteins in the frail (IL10-KO) heart.”
- Alden Gross, PhD: “Resilience and Multifactorial Stressors Among Older Adults During the COVID-19 Pandemic.”
07/01/2019-06/30/2020 (Year 17):
- Janiece Taylor, PhD: “Pilot Behavioral Intervention to Address Pain and Frailty in Older African-American Women.”
- Anne Le, MD: “Metabolomics Energy Signatures of Frailty.”
- Thorsten Leucker, MD, PhD: “PCSK9 Links Age and Frailty related Inflammation to Endothelial Cell Dysfunction”
- Naresh Punjabi, MD, PhD: “Association between Sleep Deficiency and Frailty: What harms most?”
- Amal Wanigatunga, PhD: “Daily Physical Activity Patterns and the Modifying Role of Inflammatory Markers in Frailty”
07/01/2018-06/30/2019 (Year 16):
- Janiece Taylor, PhD: “Pilot Behavioral Intervention to Address Pain and Frailty in Older African-American Women.”
- Anne Le, MD: “Metabolomics Energy Signatures of Frailty.”
- Naresh Punjabi, MD, PhD: “Association between Sleep Deficiency and Frailty: What harms most?”
07/01/2017-06/30/2018 (Year 15):
- Damani Piggott, MD: “Frailty and Angiotensin Receptor Autoantibody Activation among Persons Aging with HIV and Injection Drug Use.”
- Bonnie Swenor, PhD: “Exploring the Relationship between Visual Impairment and Frailty in Older Adults.”
- Katherine L. Wilson, PhD: “Laminopathy mechanisms as potential components of frailty.”
07/01/2016-06/30/2017 (Year 14):
- Mahendra Damarla, MD: “Effects of Poor Sleep Quality on Aging-Related Morbidity and Mortality in Acute Illness.”
- Katherine L. Wilson, PhD: “Laminopathy mechanisms as potential components of frailty.”
07/01/2015-06/30/2016 (Year 13):
- Aleksandra Leszczynska, PhD: “Effect of Age and Frailty on the Reparative Capacity of the Stem Cell Secretome.”
- Aarti Mathur, MD: “Frailty status as a predictor of alterations in speech, swallowing, and quality of life after thyroidectomy in the elderly population.”
- Mara McAdams DeMarco, PhD: “Prehabilitation for Older Adults with End Stage Renal Disease on the Kidney Transplant Waitlist.”
- Nancy Schoenborn, MD: “Understanding patient preferences for prognosis communication among older adults across the spectrum of frailty.”
07/01/2014-06/30/2015 (Year 12)
- Jessica Lee, MD, Fellow, and Jeremy Walston, Division of Geriatric Medicine and Gerontology: “A Study of Muscle Strength Maintenance in Older Adults.”
- Robert G. Weiss, MD, Professor of Medicine, Division of Cardiology: “Energy Production in Frailty: Skeletal Muscle ATP Kinetics in Frail, Older Adults.”
- Honggang Cui, PhD, Assistant Professor, Department of Chemical and Biomolecular Engineering:”The Specific Delivery of Pharmaceuticals into Mitochondria.”
07/01/2013-06/30/2014 (Year 11)
- Jessica Lee, MD, Fellow, and Jeremy Walston, Division of Geriatric Medicine and Gerontology: “A Study of Muscle Strength Maintenance in Older Adults.”
- Robert G. Weiss, MD, Professor of Medicine, Division of Cardiology: “Energy Production in Frailty: Skeletal Muscle ATP Kinetics in Frail, Older Adults.”
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Honggang Cui, PhD, Assistant Professor, Department of Chemical and Biomolecular Engineering:”The Specific Delivery of Pharmaceuticals into Mitochondria.”
07/01/2012-06/30/2013 (Year 10)
- Mary Armanios, MD: “Telomere length and clinical outcomes in the Women’s Health Aging Study”
- Qian-Li Xue, PhD: “Effects of Inflammation, Hormonal Alteration and mTOR Signaling in Modulating Age-related Declines in Muscle Strength”
- Sevil Yasar, MD, PhD: “Vitamin D, frailty, inflammation and functional outcomes”
07/01/2011-06/30/2012 (Year 9)
- Qian-Li Xue, PhD: “Effects of Inflammation, Hormonal Alteration and mTOR Signaling in Modulating Age-related Declines in Muscle Strength”
- Sevil Yasar, MD, PhD: “Vitamin D, frailty, inflammation and functional outcomes”
07/01/2010-06/30/2011 (Year 8)
- Yuri Agrawal, MD: “Vestibular dysfunction and clinical implications in frailty“
- Rita Kalyani, MD: “Insulin Resistance, Energy Homeostasis, and Frailty”
- Sevil Yasar, MD, PhD: “The renin-angiotensin system and physical and cognitive frailty”
07/01/2009-06/30/2010 (Year 7)
- Ronald Cohn, MD: “Role of Increased TGF-beta signaling in age-related impairment of muscle regeneration”
- M. Daniele Fallin, PhD, and Andrew Feinberg, PhD: “The relationship between aggregate and site-specific methylation and frailty among BLSA participants”
- Sean Leng, MD, PhD: “Specific cytokines, IL-6, TNF-a, and TGF-b, regulate CXCL10 and hic-5 expression”
07/01/2008-06/30/2009 (Year 6)
- Ronald Cohn, MD: “Role of Increased TGF-beta signaling in age-related impairment of muscle regeneration”
- M. Daniele Fallin, PhD, and Andrew Feinberg, PhD: “The relationship between aggregate and site-specific methylation and frailty among BLSA participants”
- Sean Leng, MD, PhD: “Specific cytokines, IL-6, TNF-a, and TGF-b, regulate CXCL10 and hic-5 expression”
06/01/2007 – 05/31/2008 (Year 5)
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Dan Arking, PhD: “Assessment of mitochondrial DNA variation in frailty”
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Enid Neptune, MD: “Transcriptional analysis of the aged lung phenotype”
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Erwin Tan, MD: “The Effect of High-Intensity Volunteering on the Risk of Frailty”
06/01/2006 – 05/31/2007 (Year 4)
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Dan Arking, PhD: “Assessment of mitochondrial DNA variation in frailty”
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Enid Neptune, MD: “Transcriptional analysis of the aged lung phenotype”
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Erwin Tan, MD: “The Effect of High-Intensity Volunteering on the Risk of Frailty”
06/01/2005 – 05/31/2006 (Year 3)
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Ravi Varadhan, PhD: “Evaluating the Role of Glucocorticoid Resistance in Frailty”
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Michelle Mielke, PhD: “Brain-derived and peripheral lipid levels as predictors of cognitive and physical frailty”
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Richard Semba, MD, Jeremy Walston, MD: “Selenium supplementation”
06/01/2004 – 05/31/2005 (Year 2)
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Jeremy Walston, MD: “IL-6 Gene Variation and Phenotypes Related to Frailty”
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Paulo Chaves, MD, PhD: “Heart Rate Variability, Hemoglobin, and Frailty Status in Disabled, Community-Dwelling Older Adults: A Pilot Study within the Women’s Health and Aging Study”
06/01/2003 – 05/31/2004 (Year 1)
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Jeremy Walston, MD: “IL-6 Gene Variation and Phenotypes Related to Frailty”
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Paulo Chaves, MD, PhD:“Heart Rate Variability, Hemoglobin, and Frailty Status in Disabled, Community-Dwelling Older Adults: A Pilot Study within the Women’s Health and Aging Study”