Previous and Current Projects – Pilot and Exploratory Studies Core

Pilot/Exploratory Studies Core

Overview
Key Accomplishments
Available Resources
Key Personnel

OAIC-Supported Pilot Studies

07/01/2022-06/30/2023 (Year 20):

• Najim Dehak, PhD, and Laureano Moro Velazquez, PhD: “Artificial intelligence-based phenotypic biosignals of frailty.”
• Nicola Heller, PhD, and Franco D’Alessio, MD: ““Investigating changes in monocyte-macrophage phenotype and inflammation in older frail adults.”
• Lee Goeddel, MD, MPH: “A Pilot Study to Identify Frail Patients Prior to Surgery and Implement a Novel Social Work- Focused Preoperative Intervention.”
• Sashank Reddy, MD, PhD: “Uncovering the role of chronic inflammatory signals in frailty and regenerative decline in aged skin.”
• Amal Wanigatunga, PhD: “The Effects of a Proof-of-Concept Sedentary Reduction Program on Metabolism in Prefrail Older Adults.”

07/01/2021-06/30/2022 (Year 19):

• Lee Goeddel, MD, MPH: “A Pilot Study to Identify Frail Patients Prior to Surgery and Implement a Novel Social Work- Focused Preoperative Intervention.”
• Thorsten Leucker, MD, PhD: “PCSK9 Links Age and Frailty related Inflammation to Endothelial Cell Dysfunction”
• Reyhan Westbrook, PhD: “The Effects of Tryptophan Degradation Pathway Manipulation on Metabolism, Healthspan and Lifespan in Mice.”

07/01/2020-06/30/2021 (Year 18):

• Janiece Taylor, PhD: “Pilot Behavioral Intervention to Address Pain and Frailty in Older African-American Women.”
• Anne Le, MD: “Metabolomics Energy Signatures of Frailty.” 
• Thorsten Leucker, MD, PhD: “PCSK9 Links Age and Frailty related Inflammation to Endothelial Cell Dysfunction”
• Tae Chung, MD: ” Effects of Neurotoxic Kynurenines on Peripheral Nerve Regeneration.”
• Reyhan Westbrook, PhD: “The Effects of Tryptophan Degradation Pathway Manipulation on Metabolism, Healthspan and Lifespan in Mice.”
• Kathy Wilson, PhD: “Analysis of lamin A/C-associated proteins in the frail (IL10-KO) heart.”
• Alden Gross, PhD: “Resilience and Multifactorial Stressors Among Older Adults During the COVID-19 Pandemic.”

07/01/2019-06/30/2020 (Year 17):

• Janiece Taylor, PhD: “Pilot Behavioral Intervention to Address Pain and Frailty in Older African-American Women.”
• Anne Le, MD: “Metabolomics Energy Signatures of Frailty.” 
• Thorsten Leucker, MD, PhD: “PCSK9 Links Age and Frailty related Inflammation to Endothelial Cell Dysfunction”
• Naresh Punjabi, MD, PhD: “Association between Sleep Deficiency and Frailty: What harms most?”
• Amal Wanigatunga, PhD: “Daily Physical Activity Patterns and the Modifying Role of Inflammatory Markers in Frailty”

07/01/2018-06/30/2019 (Year 16):

• Janiece Taylor, PhD: “Pilot Behavioral Intervention to Address Pain and Frailty in Older African-American Women.”
• Anne Le, MD: “Metabolomics Energy Signatures of Frailty.” 
• Naresh Punjabi, MD, PhD: “Association between Sleep Deficiency and Frailty: What harms most?”

07/01/2017-06/30/2018 (Year 15):

• Damani Piggott, MD: “Frailty and Angiotensin Receptor Autoantibody Activation among Persons Aging with HIV and Injection Drug Use.”
• Bonnie Swenor, PhD: “Exploring the Relationship between Visual Impairment and Frailty in Older Adults.”
• Katherine L. Wilson, PhD: “Laminopathy mechanisms as potential components of frailty.” 

07/01/2016-06/30/2017 (Year 14):

• Mahendra Damarla, MD: “Effects of Poor Sleep Quality on Aging-Related Morbidity and Mortality in Acute Illness.”
• Katherine L. Wilson, PhD: “Laminopathy mechanisms as potential components of frailty.” 

07/01/2015-06/30/2016 (Year 13):

• Aleksandra Leszczynska, PhD: “Effect of Age and Frailty on the Reparative Capacity of the Stem Cell Secretome.”
• Aarti Mathur, MD: “Frailty status as a predictor of alterations in speech, swallowing, and quality of life after thyroidectomy in the elderly population.”
• Mara McAdams DeMarco, PhD: “Prehabilitation for Older Adults with End Stage Renal Disease on the Kidney Transplant Waitlist.” 
• Nancy Schoenborn, MD: “Understanding patient preferences for prognosis communication among older adults across the spectrum of frailty.”

07/01/2014-06/30/2015 (Year 12)

• Jessica Lee, MD, Fellow, and Jeremy Walston,  Division of Geriatric Medicine and Gerontology: “A Study of Muscle Strength Maintenance in Older Adults.” 
• Robert G. Weiss, MD, Professor of Medicine, Division of Cardiology: “Energy Production in Frailty:  Skeletal Muscle ATP Kinetics in Frail, Older Adults.”
• Honggang Cui, PhD, Assistant Professor, Department of Chemical and Biomolecular Engineering:”The Specific Delivery of Pharmaceuticals into Mitochondria.”

07/01/2013-06/30/2014 (Year 11)

• Jessica Lee, MD, Fellow, and Jeremy Walston, Division of Geriatric Medicine and Gerontology: “A Study of Muscle Strength Maintenance in Older Adults.” 
• Robert G. Weiss, MD, Professor of Medicine, Division of Cardiology: “Energy Production in Frailty:  Skeletal Muscle ATP Kinetics in Frail, Older Adults.”
• Honggang Cui, PhD, Assistant Professor, Department of Chemical and Biomolecular Engineering:”The Specific Delivery of Pharmaceuticals into Mitochondria.”

07/01/2012-06/30/2013 (Year 10)

• Mary Armanios, MD: “Telomere length and clinical outcomes in the Women’s Health Aging Study”
• Qian-Li Xue, PhD: “Effects of Inflammation, Hormonal Alteration and mTOR Signaling in Modulating Age-related Declines in Muscle Strength”
• Sevil Yasar, MD, PhD: “Vitamin D, frailty, inflammation and functional outcomes”

07/01/2011-06/30/2012 (Year 9)

• Qian-Li Xue, PhD: “Effects of Inflammation, Hormonal Alteration and mTOR Signaling in Modulating Age-related Declines in Muscle Strength”
• Sevil Yasar, MD, PhD: “Vitamin D, frailty, inflammation and functional outcomes”

07/01/2010-06/30/2011 (Year 8)

07/01/2009-06/30/2010 (Year 7)