JHU OAIC- sponsored Symposia at the 2012 Annual Meeting of the Gerontological Society of America
The Aging Renin-Angiotensin System and the Potential for Intervention
11/17/2012, 8 am to 9:30 am
Jeremy Walston – Chair
Peter Abadir – Co-chair
Kevin High – Discussant
Participants:
Peter Abadir: Regulation of mitochondrial biogenesis with Losartan in the heart of 150 wks old aged mice.
Tyesha Burks: Age-dependent Effects of Angiotensin II Type I Receptor Blockade on Disuse Atrophy.
Ashwin Akki: Losartan Improves Aging-Associated Decline in Myocardial Energy Metabolism.
Sevil Yasar: The Renin Angiotensin System (RAS) and Physical Function.
The IL-10-/- Frail Mouse as a Model for Age-Related Disease States
11/16/2012, 8 am to 9:30 am
Jeremy Walston – Chair
Laura Dugan – Discussant
Participants:
W. Nguyen: Behavioral assessment of the IL-10-/- mouse model of frailty suggests impairments in emotional learning and anxiety response to environment.
Laura Dugan: Progressive increases in brain inflammatory superoxide predict region-specific deficits in critical inhibitory interneurons in IL-10-/- mice.
Ashwin Akki: Skeletal Muscle Creatine Kinase ATP Kinetics are Impaired in Frail Mice.
Gautam Sikka: IL10-/- Frail Mice Develop Cardiac and Vascular Dysfunction with Increased Age.