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Johns Hopkins Center on Aging and Health


JHU OAIC- sponsored Symposia at the 2012 Annual Meeting of the Gerontological Society of America

The Aging Renin-Angiotensin System and the Potential for Intervention
11/17/2012, 8 am to 9:30 am
Jeremy Walston – Chair
Peter Abadir – Co-chair
Kevin High – Discussant
Peter Abadir:  Regulation of mitochondrial biogenesis with Losartan in the heart of 150 wks old aged mice.

Tyesha Burks:  Age-dependent Effects of Angiotensin II Type I Receptor Blockade on Disuse Atrophy.

Ashwin Akki: Losartan Improves Aging-Associated Decline in Myocardial Energy Metabolism.

Sevil Yasar: The Renin Angiotensin System (RAS) and Physical Function.

The IL-10-/- Frail Mouse as a Model for Age-Related Disease States
11/16/2012, 8 am to 9:30 am
Jeremy Walston – Chair
Laura Dugan – Discussant
W. Nguyen: Behavioral assessment of the IL-10-/- mouse model of frailty suggests impairments in emotional learning and anxiety response to environment.

Laura Dugan: Progressive increases in brain inflammatory superoxide predict region-specific deficits in critical inhibitory interneurons in IL-10-/- mice.

Ashwin Akki: Skeletal Muscle Creatine Kinase ATP Kinetics are Impaired in Frail Mice.

Gautam Sikka: IL10-/- Frail Mice Develop Cardiac and Vascular Dysfunction with Increased Age.

For more information, please click here to visit the Gerontological Society of America's 2012 Annual Meeting website

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Recent JHU OAIC Publications:

"Physical Frailty Assessment in Older Women: Can Simplification Be Achieved Without Loss of Syndrome Measurement Validity?"

"Declines and Impairment in Executive Function Predict Onset of Physical Frailty"

"The Association Between Preoperative Frailty and Postoperative Delirium After Cardiac Surgery"

"Frailty: A Tale of Two Concepts" 



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Please click here to access the online Frailty Assessment Calculator.

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