JHU OAIC investigators have recently published the following articles:
The title is “Vitamin D Supplements to Prevent Falls in Older Adults: A Dose-Response Trial." Dr. Larry Appel is the PI, and the award will provide approximately $10 million in funding over a 6-year period. The trial will enroll over 1,000 community-dwelling older adults, including a large sample of African Americans, into a randomized trial to study the benefits of different doses of Vitamin D supplementation to prevent falls. This successful application represent a strong partnerships developing between faculty in the Welch Center, COAH and OAIC. Key faculty co-investigators on the project from COAH and the Division include Drs. Roth, Walston, Burton, Kalyani, Szanton and Schrack.
Reyhan Westbrook, Ph.D., OAIC post-doctoral fellow, was awarded 1st prize at the 7th Annual Research on Aging Showcase in the Post-Doctoral Fellow & Junior Faculty division. This poster competition is an annual event sponsored by the Gerontology Interest Group in the Johns Hopkins Bloomberg School of Public Health. Dr. Westbrooks's poster presentation is entitled, "The Metabolic Characterization of Interleukin-10tm1Cgn Mouse." Congraulations to Dr. Westbrook and his colleagues.
Drs. Walston, Varadhan and Xue presented the symposium, "Beyond Epidemiological Assessment: Frailty Syndrome Identification as the Key for Clinical Management, Biological Discovery, and Intervention Development" at the 2014 International Conference on Frailty and Sarcopenia Research in Barcelona, Spain. Click here for the symposium overview and abstracts.
The JHU OAIC is currently seeking candidates for Research Career Development Core support. Please click here for more information. Applications are due March 15, 2014.
Congratulations to Division of Geriatric Medicine faculty members Dr. Jeremy Walston and Dr. Peter Abadir on their recent Maryland Innovation Initiative (MII) Award. This $100,000 award is meant to accelerate their ongoing efforts to commercialize a novel wound care strategy. This work is based on small Pilot research by Dr. Peter Adadir, and Pilot research by Dr. Ronald Cohn and Dr. Tyesha Burks.
Using data from the Cardiovascular Health Study and InCHIANTI cohorts, Drs. Amy Matteini and Jeremy Walston recently published a genome-wide association study identifying multiple genetic loci significantly associated with serum interleukin-18 and interleukin-1 receptor antagonist. In particular, a novel association was observed between serum IL-18 and a region of chromosome two that contains the NLRC4 gene, an inflammasome that may be an important trigger of activation of chronic inflammation in older adults.
Congratulations to Dr. Jeremy Walston for being selected as a recipient of the 2013 Glenn Award for Research in Biological Mechanisms of Aging. The Glenn Awards provide unsolicited funds for laboratory development to outstanding researchers investigating the biology of aging. He was selected from nominees provided by a nationally recognized scientific advisory committee. The funds will be utilized to purchase laboratory equipment and to fund pilot programs in the Biology of Healthy Aging Program.
Drs. Jeremy Walston and Karen Bandeen-Roche have received renewed funding of the Hopkins Claude D. Pepper Older Americans Independence Center (OAIC) to continue ongoing research efforts that aim to determine the etiology of frailty and facilitate the development of interventions for older adults. Please click here for the JHM Press Release.
Dr. Damani Piggott has received a K23 award from the National Institute of Allergies and Infectious Diseases to study determinants and consequences of frailty among aging HIV-infected persons. This project receives external support from the JHU OAIC.
Research by Dr. Mara McAdams DeMarco and colleagues have shown a high prevalence of frailty among individuals undergoing hemodialysis. Frailty was also found to be a strong, independent predictor of mortality and number of hospitalizations among this population.
Drs. Ravi Varadhan, Jeremy Walston and colleagues have identified a simple additive index of biomarkers (serum interleukin-6 and soluble tumor necrosis factor-α receptor-1) that best captures the effect of chronic inflammation on mortality in older adults. This biomarker index provides a biologically informed, aggregate measure of inflammation for improved risk assessment and further biological study of inflammatory pathways, including those related to frailty in older adults.