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Johns Hopkins Center on Aging and Health

Pilot/Exploratory Studies Core
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Key Accomplishments
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OAIC-Supported Pilot Studies

07/01/2015-06/30/2016 (Year 13):

  • Aleksandra Leszczynska, PhD: "Effect of Age and Frailty on the Reparative Capacity of the Stem Cell Secretome."
  • Aarti Mathur, MD: "Frailty status as a predictor of alterations in speech, swallowing, and quality of life after thyroidectomy in the elderly population."
  • Mara McAdams DeMarco, PhD: "Prehabilitation for Older Adults with End Stage Renal Disease on the Kidney Transplant Waitlist." 
  • Nancy Schoenborn, MD: "Understanding patient preferences for prognosis communication among older adults across the spectrum of frailty."

07/01/2014-06/30/2015 (Year 12)

  • Jessica Lee, MD, Fellow, and Jeremy Walston,  Division of Geriatric Medicine and Gerontology: "A Study of Muscle Strength Maintenance in Older Adults." 
  • Robert G. Weiss, MD, Professor of Medicine, Division of Cardiology: "Energy Production in Frailty:  Skeletal Muscle ATP Kinetics in Frail, Older Adults."
  • Honggang Cui, PhD, Assistant Professor, Department of Chemical and Biomolecular Engineering:"The Specific Delivery of Pharmaceuticals into Mitochondria."

07/01/2013-06/30/2014 (Year 11)

  • Jessica Lee, MD, Fellow, and Jeremy Walston, Division of Geriatric Medicine and Gerontology: "A Study of Muscle Strength Maintenance in Older Adults." 
  • Robert G. Weiss, MD, Professor of Medicine, Division of Cardiology: "Energy Production in Frailty:  Skeletal Muscle ATP Kinetics in Frail, Older Adults."
  • Honggang Cui, PhD, Assistant Professor, Department of Chemical and Biomolecular Engineering:"The Specific Delivery of Pharmaceuticals into Mitochondria."

07/01/2012-06/30/2013 (Year 10)

  • Mary Armanios, MD: “Telomere length and clinical outcomes in the Women’s Health Aging Study"
  • Qian-Li Xue, PhD: “Effects of Inflammation, Hormonal Alteration and mTOR Signaling in Modulating Age-related Declines in Muscle Strength”
  • Sevil Yasar, MD, PhD: “Vitamin D, frailty, inflammation and functional outcomes”

07/01/2011-06/30/2012 (Year 9)

  • Qian-Li Xue, PhD: “Effects of Inflammation, Hormonal Alteration and mTOR Signaling in Modulating Age-related Declines in Muscle Strength”
  • Sevil Yasar, MD, PhD: “Vitamin D, frailty, inflammation and functional outcomes”

07/01/2010-06/30/2011 (Year 8)

  • Yuri Agrawal, MD: "Vestibular dysfunction and clinical implications in frailty"
  • Rita Kalyani, MD: “Insulin Resistance, Energy Homeostasis, and Frailty
  • Sevil Yasar, MD, PhD: “The renin-angiotensin system and physical and cognitive frailty

07/01/2009-06/30/2010 (Year 7)

  • Ronald Cohn, MD: "Role of Increased TGF-beta signaling in age-related impairment of muscle regeneration"
  • M. Daniele Fallin, PhD, and Andrew Feinberg, PhD: “The relationship between aggregate and site-specific methylation and frailty among BLSA participants”
  • Sean Leng, MD, PhD: “Specific cytokines, IL-6, TNF-a, and TGF-b, regulate CXCL10 and hic-5 expression”

07/01/2008-06/30/2009 (Year 6)

  • Ronald Cohn, MD: "Role of Increased TGF-beta signaling in age-related impairment of muscle regeneration"
  • M. Daniele Fallin, PhD, and Andrew Feinberg, PhD: “The relationship between aggregate and site-specific methylation and frailty among BLSA participants”
  • Sean Leng, MD, PhD: “Specific cytokines, IL-6, TNF-a, and TGF-b, regulate CXCL10 and hic-5 expression”

06/01/2007 – 05/31/2008 (Year 5)

  • Dan Arking, PhD: “Assessment of mitochondrial DNA variation in frailty”
  • Enid Neptune, MD: “Transcriptional analysis of the aged lung phenotype”
  • Erwin Tan, MD: “The Effect of High-Intensity Volunteering on the Risk of Frailty”

06/01/2006 – 05/31/2007 (Year 4)

  • Dan Arking, PhD: “Assessment of mitochondrial DNA variation in frailty”
  • Enid Neptune, MD: “Transcriptional analysis of the aged lung phenotype”
  • Erwin Tan, MD: “The Effect of High-Intensity Volunteering on the Risk of Frailty"

06/01/2005 – 05/31/2006 (Year 3)

  • Ravi Varadhan, PhD: “Evaluating the Role of Glucocorticoid Resistance in Frailty”
  • Michelle Mielke, PhD: “Brain-derived and peripheral lipid levels as predictors of cognitive and physical frailty”
  • Richard Semba, MD, Jeremy Walston, MD: “Selenium supplementation"

06/01/2004 – 05/31/2005 (Year 2)

  • Jeremy Walston, MD: “IL-6 Gene Variation and Phenotypes Related to Frailty”
  • Paulo Chaves, MD, PhD: “Heart Rate Variability, Hemoglobin, and Frailty Status in Disabled, Community-Dwelling Older Adults: A Pilot Study within the Women’s Health and Aging Study”
     
06/01/2003 – 05/31/2004 (Year 1)
 
  • Jeremy Walston, MD: “IL-6 Gene Variation and Phenotypes Related to Frailty”
  • Paulo Chaves, MD, PhD:“Heart Rate Variability, Hemoglobin, and Frailty Status in Disabled, Community-Dwelling Older Adults: A Pilot Study within the Women’s Health and Aging Study"
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OAIC NEWS

Recent JHU OAIC Publications:

"Frailty Assessment Instruments: Systematic Characterization of the Uses and Conexts of Highly-Cited Instruments."

"Frailty, Inflammation, and Mortality Among Persons Aging with HIV Infection and Injection Drug Use"

"Frailty in Older Adults: A Nationally Representative Profile in the United States"

"Frailty: A Tale of Two Concepts" 

More

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Announcements

Please click here to access the online Frailty Assessment Calculator.

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