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Johns Hopkins Center on Aging and Health

Pilot/Exploratory Studies Core
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Key Publications

Please click here for a full list of JHU OAIC Publications.

Selected Publications by OAIC-supported Pilot Investigators:

Arking DE, Fallin DM, Li T, Beamer BA, Xue QL, Fried LP, Chakravarti A, Walston JD. Variation I the Ciliary Neurotrophic Factor Gene and Muscle Strength in Older Caucasian Women. Journal of the American Geriatrics Society, 2006; May;54(5):823-6.

Burks TN, Andres-Mateo, E. Marx R, Mejias R. Van Erp C, Simmers JL, Walston JD, Ward CW, Cohn RD. Losartan restores skeletal muscle remodeling and protects against disuse atrophy in sarcopenia. Sci Trans Med. In Press.

Chaves PHM, Carlson MC, Guralnik JM, Ferrucci L, Semba R, Fried LP.  Association of Mild Anemia with Executive Cognitive Function Impairment in Community-Dwelling Older Women: The Women’s Health and Aging Study II.  J Am Geriatr Soc. 2006 Sep;54(9):1429-35. PMID: 16970654.

Chaves PH, Semba RD, Leng SX, Woodman RC, Ferrucci L, Guralnik JM, Fried LP.  Impact of Anemia and Cardiovascular Disease on Frailty Status of Community-Dwelling Older Women: The Women’s Health and Aging Studies I and II.  J Gerontol Med Sci, 2005 June;60A:6:729-735. PMID: 15983175.  

Mielke MM, Xue QL, Zhou J, Chaves PH, Fried LP, Carlson MC. Baseline Serum Cholesterol Is Selectively Associated With Motor Speed and Not Rates of Cognitive Decline: The Women's Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2008 Jun;63(6):619-24.

Mielke MM, Bandaru VV, Haughey NJ, Rabins PV, Lyketsos CG, Carlson MC. Serum sphingomyelins and ceramides are early predictors of memory impairment. Neurobiol Aging. 2008 May 1. [Epub ahead of print]

Semba RD, Ferrucci L, Sun K, Walston J, Varadhan R, Guralnik JM, Fried LP.  Oxidative stress and severe walking disability among older women. Am J Med. 2007 Dec;120(12):1084-9. PMID: 18060930.

Semba RD, Ricks MO, Ferrucci L, Xue QL, Guralnik JM, Fried LP. Low serum selenium is associated with anemia among older adults in the United States. Eur J Clin Nutr. 2007 Sep 5; [Epub ahead of print]. PMID: 17805227.

Tan EJ, Xue QL, Li T, Carlson MC, Fried LP. Volunteering: a physical activity intervention for older adults--The Experience Corps program in Baltimore. J Urban Health. 2006 Sep;83(5):954-69. PMID: 16763775.

Varadhan R, Walston J, Cappola AR, Carlson MC, Wand GS, Fried LP.  Higher Levels and Blunted Diurnal Variation of Cortisol in Frail Older Women.  J Gerontol A Biol Sci Med Sci 2008 63: 190-195.

Varadhan R., Roland C. Simple and globally-convergent methods for accelerating the convergence of any EM algorithm. Scand J Statist, 2008 (In press).

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Recent JHU OAIC Publications:

"Physical Frailty Assessment in Older Women: Can Simplification Be Achieved Without Loss of Syndrome Measurement Validity?"

"Declines and Impairment in Executive Function Predict Onset of Physical Frailty"

"The Association Between Preoperative Frailty and Postoperative Delirium After Cardiac Surgery"

"Frailty: A Tale of Two Concepts" 



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Please click here to access the online Frailty Assessment Calculator.

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