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Aging and Health


Biological Mechanisms Core (Resource Core 2)
Key Accomplishments
Past and Current Projects
Available Resources

Key Personnel

The leadership of the Biological Mechanism Core *RC-2) includes:

  • Aravinda Chakravarti, PhD, Core Director, Professor of Medicine in the Institute for Genetic Medicine at Johns Hopkins University School of Medicine
  • Jeremy Walston, MD, Co-Director (clinical medicine), Professor of Geriatric Medicine in the Johns Hopkins University School of Medicine
  • Dan Arking, PhD, Co-Director (genomics), Associate Professor of Genetics in the Institute for Genetic Medicine at Johns Hopkins University School of Medicine.

Interactions built into the RC-2 between geneticists, biostatisticians, genetic epidemiologists and geriatricians have facilitated greatly improved access to the latest and most efficient genotyping technology, and to an analytical infrastructure that can be utilized to understand the role of the frailty syndrome in disease presentation and outcomes.

In addition, RC-2 leaders provide junior investigators and others interested in frailty and aging-related conditions with study design expertise and facilitate access to large populations of older adults with previously measured phenotypic data relevant to frailty.

This helps to facilitate the identification of the genetic causes or risk factors underlying frailty and will directly lead to improved clinical research and treatments, the aims of which include the prevention and amelioration of the premature onset and progression of frailty associated with aging.

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Investigators from the JHU OAIC have recently published the following articles:

Drs. Jeremy Walston and Karen Bandeen-Roche, "Frailty: A Tale of Two Concepts," in the journal, BMC Medicine

Dr. Bandeen-Roche and colleagues, "Frailty in Older Adults: A Nationally Representative Profile in the United States" in the Journals of Gerontology: Medical Sciences (PubMed) (Press Release)

Dr. Damani Piggott and colleagues, "Frailty, Inflammation, and Mortality Among Persons Aging with HIV Infection and Injection Drug Use" in the Journals of GerontologyP Medical Sciences


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Please click here for more information about the online Frailty Assessment Tool.

The JHU OAIC is currently accepting proposals for research funding though its Pilot/Exploratory Studies Core, Biostatistics Core, and Biological Mechanisms Core.  Applications are due by July 10, 2015.

Please click here to learn about our Pepper Scholars Program, a monthly collaborative initiative for investigators interested in ongoing aging and frailty research at the Johns Hopkins OAIC.

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