The Older Americans Independence Center's Clinical Translation and Recruitment Core (Resource Core 3, or RC-3), has been developed in response to the need to accelerate the translation of important biological findings related to frailty into clinical studies, and also to train and support junior investigators proposing clinical investigations in frail, older adults. This initiative is closely aligned with the JHU Division of Geriatric Medicine and Gerontology's goals of integrating clinical practice with research, will be in large part funded by divisional philanthropic resources. The specific aims of RC-3 are 1) to provide supported OAIC investigators with comprehensive training and mentorship in clinical research, 2) to provide the oversight necessary to ensure optimal and safe performance of clinical studies, 3) to provide clinical research space and assistance with all aspects as needed of protocol development, data collection, and recruitment of human subjects, 4) to maintain and grow an active frailty registry of older adults characterized for frailty and consented to be contacted for additional aging and frailty related studies. These aims are carried out in close collaboration with the leaders of all other resource cores, which ensures optimal study design, implementation, and interpretation of results. In addition, this core plays a crucial role in the training of junior investigators engaged in RCDC activites and in pilot/exploratory studies, which currently includes clinical studies involving human subjects that target questions related to inflammation, mitochondrial function, and the angiotensin system. RC-3 will accelerate the pace of translation of the important biological findings being generated in this OAIC into clinical studies that will focus on the maintenance of independence in older adults.